Combined Targeting of Estrogen Receptor Alpha and XPO1 Prevent Akt Activation, Remodel Metabolic Pathways and Induce Autophagy to Overcome Tamoxifen Resistance

A majority of breast cancer specific deaths in women with ERα (+) tumors occur due to metastases that are resistant to endocrine therapy. There is a critical need for novel therapeutic approaches to resensitize recurrent ERα (+) tumors to endocrine therapies. The objective of this study was to eluci...

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Библиографические подробности
Опубликовано в: :Cancers (Basel)
Главные авторы: Kulkoyluoglu-Cotul, Eylem, Smith, Brandi Patrice, Wrobel, Kinga, Chen Zhao, Yiru, Chen, Karen Lee Ann, Hieronymi, Kadriye, Imir, Ozan Berk, Duong, Kevin, O’Callaghan, Caitlin, Mehta, Aditi, Sahoo, Sunati, Haley, Barbara, Chang, Hua, Landesman, Yosef, Madak-Erdogan, Zeynep
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6520695/
https://ncbi.nlm.nih.gov/pubmed/30987380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11040479
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