Combined Targeting of Estrogen Receptor Alpha and XPO1 Prevent Akt Activation, Remodel Metabolic Pathways and Induce Autophagy to Overcome Tamoxifen Resistance

A majority of breast cancer specific deaths in women with ERα (+) tumors occur due to metastases that are resistant to endocrine therapy. There is a critical need for novel therapeutic approaches to resensitize recurrent ERα (+) tumors to endocrine therapies. The objective of this study was to eluci...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Kulkoyluoglu-Cotul, Eylem, Smith, Brandi Patrice, Wrobel, Kinga, Chen Zhao, Yiru, Chen, Karen Lee Ann, Hieronymi, Kadriye, Imir, Ozan Berk, Duong, Kevin, O’Callaghan, Caitlin, Mehta, Aditi, Sahoo, Sunati, Haley, Barbara, Chang, Hua, Landesman, Yosef, Madak-Erdogan, Zeynep
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6520695/
https://ncbi.nlm.nih.gov/pubmed/30987380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11040479
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