Senescent Hepatocytes in Decompensated Liver Show Reduced UPR(MT) and Its Key Player, CLPP, Attenuates Senescence In Vitro

BACKGROUND AND AIMS: Non-dividing hepatocytes in end-stage liver disease indicates permanent growth arrest similar to senescence. Identifying senescence in vivo is often challenging and mechanisms inhibiting senescence are poorly understood. In lower organisms mitochondrial unfolded protein response...

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Detalhes bibliográficos
Publicado no:Cell Mol Gastroenterol Hepatol
Main Authors: Sen, Bijoya, Rastogi, Archana, Nath, Rhisita, Shasthry, Saggere M., Pamecha, Viniyendra, Pandey, Sonika, Gupta, Kapuganti Jagadis, Sarin, Shiv K., Trehanpati, Nirupma, Ramakrishna, Gayatri
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6520637/
https://ncbi.nlm.nih.gov/pubmed/30878663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2019.03.001
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