The GPI-Linked Protein LY6A Drives AAV-PHP.B Transport across the Blood-Brain Barrier

Efficient delivery of gene therapy vectors across the blood-brain barrier (BBB) is the holy grail of neurological disease therapies. A variant of the neurotropic vector adeno-associated virus (AAV) serotype 9, called AAV-PHP.B, was shown to very efficiently deliver transgenes across the BBB in C57BL...

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Vydáno v:Mol Ther
Hlavní autoři: Hordeaux, Juliette, Yuan, Yuan, Clark, Peter M., Wang, Qiang, Martino, R. Alexander, Sims, Joshua J., Bell, Peter, Raymond, Angela, Stanford, William L., Wilson, James M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2019
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6520463/
https://ncbi.nlm.nih.gov/pubmed/30819613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.02.013
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