Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy

RTS,S/AS01E has been tested in a phase 3 malaria vaccine study with partial efficacy in African children and infants. In a cohort of 1028 subjects from one low (Bagomoyo) and two high (Nanoro, Kintampo) malaria transmission sites, we analysed IgG plasma/serum concentration and avidity to CSP (NANP-r...

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Pubblicato in:Nat Commun
Autori principali: Dobaño, Carlota, Sanz, Hèctor, Sorgho, Hermann, Dosoo, David, Mpina, Maximilian, Ubillos, Itziar, Aguilar, Ruth, Ford, Tom, Díez-Padrisa, Núria, Williams, Nana Aba, Ayestaran, Aintzane, Traore, Ousmane, Nhabomba, Augusto J., Jairoce, Chenjerai, Waitumbi, John, Agnandji, Selidji Todagbe, Kariuki, Simon, Abdulla, Salim, Aponte, John J., Mordmüller, Benjamin, Asante, Kwaku Poku, Owusu-Agyei, Seth, Tinto, Halidou, Campo, Joseph J., Moncunill, Gemma, Gyan, Ben, Valim, Clarissa, Daubenberger, Claudia
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6520358/
https://ncbi.nlm.nih.gov/pubmed/31092823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10195-z
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