Baseline exposure, antibody subclass, and hepatitis B response differentially affect malaria protective immunity following RTS,S/AS01E vaccination in African children

BACKGROUND: The RTS,S/AS01E vaccine provides partial protection against malaria in African children, but immune responses have only been partially characterized and do not reliably predict protective efficacy. We aimed to evaluate comprehensively the immunogenicity of the vaccine at peak response, t...

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Pubblicato in:BMC Med
Autori principali: Ubillos, Itziar, Ayestaran, Aintzane, Nhabomba, Augusto J, Dosoo, David, Vidal, Marta, Jiménez, Alfons, Jairoce, Chenjerai, Sanz, Hèctor, Aguilar, Ruth, Williams, Nana Aba, Díez-Padrisa, Núria, Mpina, Maximilian, Sorgho, Hermann, Agnandji, Selidji Todagbe, Kariuki, Simon, Mordmüller, Benjamin, Daubenberger, Claudia, Asante, Kwaku Poku, Owusu-Agyei, Seth, Sacarlal, Jahit, Aide, Pedro, Aponte, John J, Dutta, Sheetij, Gyan, Ben, Campo, Joseph J, Valim, Clarissa, Moncunill, Gemma, Dobaño, Carlota
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6208122/
https://ncbi.nlm.nih.gov/pubmed/30376866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12916-018-1186-4
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