Genomic SEM Provides Insights into the Multivariate Genetic Architecture of Complex Traits

Genetic correlations estimated from GWAS reveal pervasive pleiotropy across a wide variety of phenotypes. We introduce genomic structural equation modeling (Genomic SEM), a multivariate method for analyzing the joint genetic architecture of complex traits. Genomic SEM synthesizes genetic correlation...

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Detalhes bibliográficos
Publicado no:Nat Hum Behav
Main Authors: Grotzinger, Andrew D., Rhemtulla, Mijke, de Vlaming, Ronald, Ritchie, Stuart J., Mallard, Travis T., Hill, W. David, Ip, Hill F., Marioni, Riccardo E., McIntosh, Andrew M., Deary, Ian J., Koellinger, Philipp D., Harden, K. Paige, Nivard, Michel G., Tucker-Drob, Elliot M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6520146/
https://ncbi.nlm.nih.gov/pubmed/30962613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41562-019-0566-x
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