Neurotrophin Receptor TrkB Activation Is Not Required for the Postnatal Survival of Retinal Ganglion Cells in Vivo

During early postnatal development, apoptosis of retinal ganglion cells (RGCs) is regulated by target contact with the optic tectum. The neurotrophins BDNF and NT-4, but not NGF, prevent the apoptosis of retinal ganglion cells that is otherwise observed after target ablation or axotomy. Thus recepto...

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Udgivet i:Exp Neurol
Main Authors: Rohrer, Baerbel, LaVail, Matthew M., Jones, Kevin R., Reichardt, Louis F.
Format: Artigo
Sprog:Inglês
Udgivet: 2001
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6519927/
https://ncbi.nlm.nih.gov/pubmed/11681842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1006/exnr.2001.7795
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