Pharmacological Induction of a Progenitor State for the Efficient Expansion of Primary Human Hepatocytes

The liver is an organ with strong regenerative capacity, yet primary hepatocytes have a low amplification potential in vitro, a major limitation for the cell‐based therapy of liver disorders and for ex vivo biological screens. Induced pluripotent stem cells (iPSCs) may help to circumvent this obstac...

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Bibliographische Detailangaben
Veröffentlicht in:Hepatology
Hauptverfasser: Unzu, Carmen, Planet, Evarist, Brandenberg, Nathalie, Fusil, Floriane, Cassano, Marco, Perez‐Vargas, Jimena, Friedli, Marc, Cosset, François‐Loïc, Lutolf, Matthias P., Wildhaber, Barbara E., Trono, Didier
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6519263/
https://ncbi.nlm.nih.gov/pubmed/30549291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30425
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