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Humanised monoclonal antibodies neutralise pertussis toxin by receptor blockade and reduced retrograde trafficking
Pertussis toxin (PTx) is a major protective antigen produced by Bordetella pertussis that is included in all current acellular vaccines. Of several well‐characterized monoclonal antibodies binding this toxin, the humanised hu1B7 and hu11E6 antibodies are highly protective in multiple in vitro and in...
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| Publicado en: | Cell Microbiol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6519169/ https://ncbi.nlm.nih.gov/pubmed/30152075 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cmi.12948 |
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