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Humanised monoclonal antibodies neutralise pertussis toxin by receptor blockade and reduced retrograde trafficking

Pertussis toxin (PTx) is a major protective antigen produced by Bordetella pertussis that is included in all current acellular vaccines. Of several well‐characterized monoclonal antibodies binding this toxin, the humanised hu1B7 and hu11E6 antibodies are highly protective in multiple in vitro and in...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Microbiol
Prif Awduron: Acquaye‐Seedah, Edith, Huang, Yimin, Sutherland, Jamie N., DiVenere, Andrea M., Maynard, Jennifer A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6519169/
https://ncbi.nlm.nih.gov/pubmed/30152075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cmi.12948
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