Prevention of the anti-factor VIII memory B-cell response by inhibition of Bruton tyrosine kinase in experimental hemophilia A

Hemophilia A is a rare hemorrhagic disorder caused by the lack of functional pro-coagulant factor VIII. Factor VIII replacement therapy in patients with severe hemophilia A results in the development of inhibitory anti-factor VIII IgG in up to 30% of cases. To date, immune tolerance induction, with...

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Veröffentlicht in:Haematologica
Hauptverfasser: Delignat, Sandrine, Russick, Jules, Gangadharan, Bagirath, Rayes, Julie, Ing, Mathieu, Voorberg, Jan, Kaveri, Srinivas V., Lacroix-Desmazes, Sébastien
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ferrata Storti Foundation 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6518880/
https://ncbi.nlm.nih.gov/pubmed/30545924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.200279
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