Quantitative Temporal Proteomic Analysis of Vaccinia Virus Infection Reveals Regulation of Histone Deacetylases by an Interferon Antagonist

Vaccinia virus (VACV) has numerous immune evasion strategies, including multiple mechanisms of inhibition of interferon regulatory factor 3 (IRF-3), nuclear factor κB (NF-κB), and type I interferon (IFN) signaling. Here, we use highly multiplexed proteomics to quantify ∼9,000 cellular proteins and ∼...

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Pubblicato in:Cell Rep
Autori principali: Soday, Lior, Lu, Yongxu, Albarnaz, Jonas D., Davies, Colin T.R., Antrobus, Robin, Smith, Geoffrey L., Weekes, Michael P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6518873/
https://ncbi.nlm.nih.gov/pubmed/31067474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.04.042
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