Histone deacetylase 4 promotes type I interferon signaling, restricts DNA viruses, and is degraded via vaccinia virus protein C6

Interferons (IFNs) represent an important host defense against viruses. Type I IFNs induce JAK-STAT signaling and expression of IFN-stimulated genes (ISGs), which mediate antiviral activity. Histone deacetylases (HDACs) perform multiple functions in regulating gene expression and some class I HDACs...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Lu, Yongxu, Stuart, Jennifer H., Talbot-Cooper, Callum, Agrawal-Singh, Shuchi, Huntly, Brian, Smid, Andrei I., Snowden, Joseph S., Dupont, Liane, Smith, Geoffrey L.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6575207/
https://ncbi.nlm.nih.gov/pubmed/31127039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1816399116
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