Randomized, open-label, comparative phase IV study on the bioavailability of Ciclosporin Pro (Teva) versus Sandimmun® Optoral (Novartis) under fasting versus fed conditions in patients with stable renal transplants

BACKGROUND: The influence of pre- or postprandial administration on pharmacokinetics of cyclosporine is supposed to be less in gel-based formulations than in microemulsions. This study was designed to investigate the influence of a high-fat meal on the pharmacokinetic profile of the two cyclosporine...

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Publicat a:BMC Nephrol
Autors principals: Gäckler, Anja, Dolff, Sebastian, Rohn, Hana, Korth, Johannes, Wilde, Benjamin, Eisenberger, Ute, Mitchell, Anna, Kribben, Andreas, Witzke, Oliver
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6518767/
https://ncbi.nlm.nih.gov/pubmed/31088392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12882-019-1340-z
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