Novel Small Molecule MEK Inhibitor URML-3881 Enhances Cisplatin Sensitivity in Clear Cell Ovarian Cancer

Advanced clear cell ovarian cancer (CCOC) is a highly fatal malignancy with a scarcity of effective treatment options. CCOC is inherently chemotherapy resistance, but the exact mechanism of this resistance has yet to be established. Prosurvival signaling, such as through the MAPK cascade, is one way...

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Detalhes bibliográficos
Publicado no:Transl Oncol
Main Authors: Rowswell-Turner, Rachael B., Rutishauser, Jennifer A., Kim, Kyu Kwang, Khazan, Negar, Sivagnanalingam, Umayal, Jones, Aaron M., Singh, Rakesh K., Moore, Richard G.
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2019
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Original article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6517847/
https://ncbi.nlm.nih.gov/pubmed/31082584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2019.04.009
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