Active immunisation targeting nerve growth factor attenuates chronic pain behaviour in murine osteoarthritis

OBJECTIVES: Nerve growth factor (NGF) has emerged as a key driver of pain in osteoarthritis (OA) and antibodies to NGF are potent analgesics in human disease. Here, we validate a novel vaccine strategy to generate anti-NGF antibodies for reversal of pain behaviour in a surgical model of OA. METHODS:...

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Detalhes bibliográficos
Publicado no:Ann Rheum Dis
Main Authors: von Loga, Isabell S, El-Turabi, Aadil, Jostins, Luke, Miotla-Zarebska, Jadwiga, Mackay-Alderson, Jennifer, Zeltins, Andris, Parisi, Ida, Bachmann, Martin F, Vincent, Tonia L
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2019
Assuntos:
Osteoarthritis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6517802/
https://ncbi.nlm.nih.gov/pubmed/30862648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2018-214489
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