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Active immunisation targeting nerve growth factor attenuates chronic pain behaviour in murine osteoarthritis
OBJECTIVES: Nerve growth factor (NGF) has emerged as a key driver of pain in osteoarthritis (OA) and antibodies to NGF are potent analgesics in human disease. Here, we validate a novel vaccine strategy to generate anti-NGF antibodies for reversal of pain behaviour in a surgical model of OA. METHODS:...
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| 出版年: | Ann Rheum Dis |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BMJ Publishing Group
2019
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6517802/ https://ncbi.nlm.nih.gov/pubmed/30862648 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2018-214489 |
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