Structural basis of the leukocyte integrin Mac-1 I-domain interactions with the platelet glycoprotein Ib

Cell-surface receptor interactions between leukocyte integrin macrophage-1 antigen (Mac-1, also known as CR3, αMβ2, CD11b/CD18) and platelet glycoprotein Ibα (GPIbα) are critical to vascular inflammation. To define the key residues at the binding interface, we used nuclear magnetic resonance (NMR) t...

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Veröffentlicht in:Blood Adv
Hauptverfasser: Morgan, Juliet, Saleem, Muhammad, Ng, Ruiqi, Armstrong, Caroline, Wong, Szu S., Caulton, Simon G., Fickling, Alice, Williams, Huw E. L., Munday, Adam D., López, José A., Searle, Mark S., Emsley, Jonas
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2019
Schlagworte:
Thrombosis and Hemostasis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6517656/
https://ncbi.nlm.nih.gov/pubmed/31053572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018027011
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