Transcriptional Suppression of CPI-17 Gene Expression in Vascular Smooth Muscle Cells by Tumor Necrosis Factor, Krüppel-Like Factor 4, and Sp1 Is Associated with Lipopolysaccharide-Induced Vascular Hypocontractility, Hypotension, and Mortality

Vasodilatory shock in sepsis is caused by the failure of the vasculature to respond to vasopressors, which results in hypotension, multiorgan failure, and ultimately patient death. Recently, it was reported that CPI-17, a key player in the regulation of smooth muscle contraction, was downregulated b...

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Udgivet i:Mol Cell Biol
Main Authors: Zhao, Guogang, Zhong, Yu, Su, Wen, Liu, Shu, Song, Xiulong, Hou, Tianfei, Mu, Xufang, Gong, Ming Cui, Guo, Zhenheng
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6517596/
https://ncbi.nlm.nih.gov/pubmed/30936247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00070-19
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