Role of Calcium-independent Phospholipase A(2)β in High Glucose-induced Activation of RhoA, Rho Kinase, and CPI-17 in Cultured Vascular Smooth Muscle Cells and Vascular Smooth Muscle Hypercontractility in Diabetic Animals

Previous studies suggest that high glucose-induced RhoA/Rho kinase/CPI-17 activation is involved in diabetes-associated vascular smooth muscle hypercontractility. However, the upstream signaling that links high glucose and RhoA/Rho kinase/CPI-17 activation is unknown. Here we report that calcium-ind...

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Detalhes bibliográficos
Main Authors: Xie, Zhongwen, Gong, Ming C., Su, Wen, Xie, Dongping, Turk, John, Guo, Zhenheng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838285/
https://ncbi.nlm.nih.gov/pubmed/20086008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.057711
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