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The mechanism of DNA unwinding by the eukaryotic replicative helicase

Accurate DNA replication is tightly regulated in eukaryotes to ensure genome stability during cell division and is performed by the multi-protein replisome. At the core an AAA+ hetero-hexameric complex, Mcm2-7, together with GINS and Cdc45 form the active replicative helicase Cdc45/Mcm2-7/GINS (CMG)...

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Vydáno v:Nat Commun
Hlavní autoři: Burnham, Daniel R., Kose, Hazal B., Hoyle, Rebecca B., Yardimci, Hasan
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6517413/
https://ncbi.nlm.nih.gov/pubmed/31089141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09896-2
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