Autophagy inhibition specifically promotes epithelial-mesenchymal transition and invasion in RAS-mutated cancer cells

Macroautophagy/autophagy inhibition is a novel anticancer therapeutic strategy, especially for tumors driven by mutant RAS. Here, we demonstrate that autophagy inhibition in RAS-mutated cells induces epithelial-mesenchymal transition (EMT), which is associated with enhanced tumor invasion. This is a...

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Dettagli Bibliografici
Pubblicato in:Autophagy
Autori principali: Wang, Yihua, Xiong, Hua, Liu, Dian, Hill, Charlotte, Ertay, Ayse, Li, Juanjuan, Zou, Yanmei, Miller, Paul, White, Eileen, Downward, Julian, Goldin, Robert D, Yuan, Xianglin, Lu, Xin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2019
Soggetti:
Research Paper - Translational
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6517269/
https://ncbi.nlm.nih.gov/pubmed/30782064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1569912
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