Effects of Genetic Variants Associated with Familial Hypercholesterolemia on Low-Density Lipoprotein-Cholesterol Levels and Cardiovascular Outcomes in the Million Veteran Program

BACKGROUND: Familial hypercholesterolemia (FH) is characterized by inherited high levels of low-density lipoprotein cholesterol (LDL-C) and premature coronary heart disease (CHD). Over a thousand low-frequency variants in LDLR, APOB and PCSK9 have been implicated in FH but few have been examined at...

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Pubblicato in:Circ Genom Precis Med
Autori principali: Sun, Yan V., Damrauer, Scott M., Hui, Qin, Assimes, Themistocles L., Ho, Yuk-Lam, Natarajan, Pradeep, Klarin, Derek, Huang, Jie, Lynch, Julie, DuVall, Scott L., Pyarajan, Saiju, Honerlaw, Jacqueline P., Gaziano, J. Michael, Cho, Kelly, Rader, Daniel J., O’Donnell, Christopher J., Tsao, Philip S., Wilson, Peter W. F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516478/
https://ncbi.nlm.nih.gov/pubmed/31106297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGEN.118.002192
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