Noncoding variations in Cyp24a1 gene are associated with Klotho‐mediated aging phenotypes in different strains of mice

In mutant mice, reduced levels of Klotho promoted high levels of active vitamin D in the serum. Genetic or dietary manipulations that diminished active vitamin D alleviated aging‐related phenotypes caused by Klotho down‐regulation. The hypomorphic Klotho [kl/kl] allele that decreases Klotho expressi...

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Gepubliceerd in:Aging Cell
Hoofdauteurs: Singh, Amit, Verma, Anjali, Sallin, Michelle A., Lang, Florian, Sen, Ranjan, Sen, Jyoti Misra
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516175/
https://ncbi.nlm.nih.gov/pubmed/30920112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12949
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