The angiotensin‐(1‐7)/Mas receptor axis protects from endothelial cell senescence via klotho and Nrf2 activation

Endothelial cell senescence is a hallmark of vascular aging that predisposes to vascular disease. We aimed to explore the capacity of the renin–angiotensin system (RAS) heptapeptide angiotensin (Ang)‐(1‐7) to counteract human endothelial cell senescence and to identify intracellular pathways mediati...

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Publicat a:Aging Cell
Autors principals: Romero, Alejandra, San Hipólito‐Luengo, Álvaro, Villalobos, Laura A., Vallejo, Susana, Valencia, Inés, Michalska, Patrycja, Pajuelo‐Lozano, Natalia, Sánchez‐Pérez, Isabel, León, Rafael, Bartha, José Luis, Sanz, María Jesús, Erusalimsky, Jorge D., Sánchez‐Ferrer, Carlos F., Romacho, Tania, Peiró, Concepción
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
Matèries:
Original Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516147/
https://ncbi.nlm.nih.gov/pubmed/30773786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12913
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