The angiotensin‐(1‐7)/Mas receptor axis protects from endothelial cell senescence via klotho and Nrf2 activation

Endothelial cell senescence is a hallmark of vascular aging that predisposes to vascular disease. We aimed to explore the capacity of the renin–angiotensin system (RAS) heptapeptide angiotensin (Ang)‐(1‐7) to counteract human endothelial cell senescence and to identify intracellular pathways mediati...

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Sparad:
Bibliografiska uppgifter
I publikationen:Aging Cell
Huvudupphovsmän: Romero, Alejandra, San Hipólito‐Luengo, Álvaro, Villalobos, Laura A., Vallejo, Susana, Valencia, Inés, Michalska, Patrycja, Pajuelo‐Lozano, Natalia, Sánchez‐Pérez, Isabel, León, Rafael, Bartha, José Luis, Sanz, María Jesús, Erusalimsky, Jorge D., Sánchez‐Ferrer, Carlos F., Romacho, Tania, Peiró, Concepción
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2019
Ämnen:
Original Papers
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516147/
https://ncbi.nlm.nih.gov/pubmed/30773786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12913
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