S‐1 plus Raltitrexed for Refractory Metastatic Colorectal Cancer: A Phase II Trial

LESSONS LEARNED. The upregulation of dihydropyrimidine dehydrogenase (DPD) and thymidylate synthase (TS) are important mechanisms of resistance to 5‐fluorouracil (5‐FU) in metastatic colorectal cancer (mCRC) after long exposure to 5‐FU. S‐1 (containing a DPD inhibitor) combined with raltitrexed (a T...

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Detalhes bibliográficos
Publicado no:Oncologist
Main Authors: Chen, Ye, Wu, Jing, Cheng, Ke, Li, Zhi‐Ping, Luo, De‐Yun, Qiu, Meng, Gou, Hong‐Feng, Yi, Cheng, Li, Qiu, Wang, Xin, Yang, Yu, Cao, Dan, Shen, Ya‐Li, Bi, Feng, Liu, Ji‐Yan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2019
Assuntos:
Clinical Trial Results
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516113/
https://ncbi.nlm.nih.gov/pubmed/30651398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2018-0901
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