Bumetanide-Derived Aquaporin 1 Inhibitors, AqB013 and AqB050 Inhibit Tube Formation of Endothelial Cells through Induction of Apoptosis and Impaired Migration In Vitro

AqB013 and AqB050 compounds inhibit aquaporin 1 (AQP1), a dual water and ion channel implicated in tumour angiogenesis. We tested AqB013 and AqB050 either as monotherapy or in combination on tube formation of murine endothelial cells (2H-11 and 3B-11) and human umbilical vascular endothelial cells (...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Tomita, Yoko, Palethorpe, Helen M., Smith, Eric, Nakhjavani, Maryam, Townsend, Amanda R., Price, Timothy J., Yool, Andrea J., Hardingham, Jennifer E.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6515555/
https://ncbi.nlm.nih.gov/pubmed/31013775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20081818
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