Effects of acute N-acetylcysteine challenge on cortical glutathione and glutamate in schizophrenia: A pilot in vivo proton magnetic resonance spectroscopy study

Findings from in vivo brain proton magnetic resonance spectroscopy ((1)H MRS) and preclinical studies have suggested region- and medication status-dependent increases in glutamate (Glu) levels and deficiencies in glutathione (GSH) levels in schizophrenia. N-acetylcysteine (NAC), a GSH synthesis prec...

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Udgivet i:Psychiatry Res
Main Authors: Girgis, Ragy R., Baker, Seth, Mao, Xiangling, Gil, Roberto, Javitt, Daniel C., Kantrowitz, Joshua T., Gu, Meng, Spielman, Daniel M., Ojeil, Najate, Xu, Xiaoyan, Abi-Dargham, Anissa, Shungu, Dikoma C., Kegeles, Lawrence S.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6515541/
https://ncbi.nlm.nih.gov/pubmed/30884334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.psychres.2019.03.018
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