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Synergistic Effect of Low Molecular Weight Polyethylenimine and Polyethylene Glycol Components in Dynamic Nonviral Vector Structure, Toxicity, and Transfection Efficiency

When studying polyethylenimine derivatives as nonviral vectors for gene delivery, among the important issues to be addressed are high toxicity, low transfection efficiency, and nucleic acid polyplex condensation. The molecular weight of polyethylenimine, PEGylation, biocompatibility and, also, supra...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Craciun, Bogdan Florin, Gavril, Gabriela, Peptanariu, Dragos, Ursu, Laura Elena, Clima, Lilia, Pinteala, Mariana
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6515267/
https://ncbi.nlm.nih.gov/pubmed/31013863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24081460
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