Synergistic Effect of Low Molecular Weight Polyethylenimine and Polyethylene Glycol Components in Dynamic Nonviral Vector Structure, Toxicity, and Transfection Efficiency

When studying polyethylenimine derivatives as nonviral vectors for gene delivery, among the important issues to be addressed are high toxicity, low transfection efficiency, and nucleic acid polyplex condensation. The molecular weight of polyethylenimine, PEGylation, biocompatibility and, also, supra...

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Bibliographic Details
Published in:Molecules
Main Authors: Craciun, Bogdan Florin, Gavril, Gabriela, Peptanariu, Dragos, Ursu, Laura Elena, Clima, Lilia, Pinteala, Mariana
Format: Artigo
Language:Inglês
Published: MDPI 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6515267/
https://ncbi.nlm.nih.gov/pubmed/31013863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24081460
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