Role of SUMOylation in differential ERα transcriptional repression by tamoxifen and fulvestrant in breast cancer cells

Antiestrogens (AEs) are widely used for treatment of estrogen receptor alpha (ERα)-positive breast cancer, but display variable degrees of partial agonism in estrogen target tissues and breast cancer (BC) cells. The fact that BC cells resistant to selective ER modulators (SERMs) like tamoxifen (Tam)...

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Udgivet i:Oncogene
Main Authors: Traboulsi, Tatiana, El Ezzy, Mohamed, Dumeaux, Vanessa, Audemard, Eric, Mader, Sylvie
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514857/
https://ncbi.nlm.nih.gov/pubmed/30190545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0468-9
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