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DAF-18/PTEN locally antagonizes insulin signalling to couple germline stem cell proliferation to oocyte needs in C. elegans

During development, stem cell populations rapidly proliferate to populate the expanding tissues and organs. During this phase, nutrient status, by systemically affecting insulin/IGF-1 signalling, largely dictates stem cell proliferation rates. In adults, however, differentiated stem cell progeny req...

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Detalhes bibliográficos
Publicado no:Development
Main Authors: Narbonne, Patrick, Maddox, Paul S., Labbé, Jean-Claude
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514392/
https://ncbi.nlm.nih.gov/pubmed/26552888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.130252
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