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Non-autonomous DAF-16/FOXO activity antagonizes age-related loss of C. elegans germline stem/progenitor cells

Stem cells maintain tissues and organs over the lifespan of individuals. How aging influences this process is unclear. Here we investigate the effects of aging on C. elegans germline stem/progenitor cells and show that the progenitor pool is depleted over time in a manner dependent on inhibition of...

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Pubblicato in:Nat Commun
Autori principali: Qin, Zhao, Hubbard, E. Jane Albert
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Pub. Group 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432587/
https://ncbi.nlm.nih.gov/pubmed/25960195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8107
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