Pterostilbene prevents hepatocyte epithelial‐mesenchymal transition in fructose‐induced liver fibrosis through suppressing miR‐34a/Sirt1/p53 and TGF‐β1/Smads signalling

BACKGROUND AND PURPOSE: Excessive fructose consumption is a risk factor for liver fibrosis. Pterostilbene protects against liver fibrosis. Here, we investigated the potential role and the mechanisms underlying the hepatocyte epithelial‐mesenchymal transition (EMT) in fructose‐induced liver fibrosis...

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Veröffentlicht in:Br J Pharmacol
Hauptverfasser: Song, Lin, Chen, Tian‐Yu, Zhao, Xiao‐Juan, Xu, Qiang, Jiao, Rui‐Qing, Li, Jian‐Mei, Kong, Ling‐Dong
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514378/
https://ncbi.nlm.nih.gov/pubmed/30632134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14573
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