Divergent Aging of Isogenic Yeast Cells Revealed through Single-Cell Phenotypic Dynamics

Although genetic mutations that alter organism’s average lifespans have been identified in aging research, our understanding of the dynamic changes during aging remains limited. Here, we integrate single-cell imaging, microfluidics, and computational modeling to investigate phenotypic divergence and...

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Veröffentlicht in:Cell Syst
Hauptverfasser: Jin, Meng, Li, Yang, O’Laughlin, Richard, Bittihn, Philip, Pillus, Lorraine, Tsimring, Lev S., Hasty, Jeff, Hao, Nan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514117/
https://ncbi.nlm.nih.gov/pubmed/30852250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2019.02.002
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