PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism

Posterior fossa type A (PFA) ependymomas exhibit very low H3K27 methylation and express high levels of EZHIP (Enhancer of Zeste Homologs Inhibitory Protein, also termed CXORF67). Here we find that a conserved sequence in EZHIP is necessary and sufficient to inhibit PRC2 catalytic activity in vitro a...

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Publicado en:Nat Commun
Autores principales: Jain, Siddhant U., Do, Truman J., Lund, Peder J., Rashoff, Andrew Q., Diehl, Katharine L., Cieslik, Marcin, Bajic, Andrea, Juretic, Nikoleta, Deshmukh, Shriya, Venneti, Sriram, Muir, Tom W., Garcia, Benjamin A., Jabado, Nada, Lewis, Peter W.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6513997/
https://ncbi.nlm.nih.gov/pubmed/31086175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09981-6
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