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EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks
The exosome is a ribonucleolytic complex that plays important roles in RNA metabolism. Here we show that the exosome is necessary for the repair of DNA double-strand breaks (DSBs) in human cells and that RNA clearance is an essential step in homologous recombination. Transcription of DSB-flanking se...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6513946/ https://ncbi.nlm.nih.gov/pubmed/31086179 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10153-9 |
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