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RPA stabilization of single-stranded DNA is critical for break-induced replication

DNA double strand breaks (DSBs) are cytotoxic lesions that must be accurately repaired to maintain genome stability. Replication protein A (RPA) plays an important role in homology-dependent repair of DSBs by protecting the single-stranded DNA (ssDNA) intermediates formed by end resection and facili...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Ruff, Patrick, Donnianni, Roberto A., Glancy, Eleanor, Oh, Julyun, Symington, Lorraine S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5218512/
https://ncbi.nlm.nih.gov/pubmed/28009302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.12.003
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