Endogenous double-stranded Alu RNA elements stimulate IFN-responses in relapsing remitting multiple sclerosis

Various sensors that detect double-stranded RNA, presumably of viral origin, exist in eukaryotic cells and induce IFN-responses. Ongoing IFN-responses have also been documented in a variety of human autoimmune diseases including relapsing-remitting multiple sclerosis (RRMS) but their origins remain...

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Pubblicato in:J Autoimmun
Autori principali: Heinrich, Maxwell J., Purcell, Caroline A, Pruijssers, Andrea J., Zhao, Yang, Spurlock, Charles F., Sriram, Subramaniam, Ogden, Kristen M, Dermody, Terence S., Scholz, Matthew B., Crooke, Philip S., Karijolich, John, Aune, Thomas M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6513682/
https://ncbi.nlm.nih.gov/pubmed/30826177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2019.02.003
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