Castration-resistant prostate cancer: Androgen receptor inactivation induces telomere DNA damage, and damage response inhibition leads to cell death

Telomere stability is important for cell viability, as cells with telomere DNA damage that is not repaired do not survive. We reported previously that androgen receptor (AR) antagonist induces telomere DNA damage in androgen-sensitive LNCaP prostate cancer cells; this triggers a DNA damage response...

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Publicat a:PLoS One
Autors principals: Reddy, Vidyavathi, Iskander, Asm, Hwang, Clara, Divine, George, Menon, Mani, Barrack, Evelyn R., Reddy, G. Prem-Veer, Kim, Sahn-Ho
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6513077/
https://ncbi.nlm.nih.gov/pubmed/31083651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0211090
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