Castration-resistant prostate cancer: Androgen receptor inactivation induces telomere DNA damage, and damage response inhibition leads to cell death

Telomere stability is important for cell viability, as cells with telomere DNA damage that is not repaired do not survive. We reported previously that androgen receptor (AR) antagonist induces telomere DNA damage in androgen-sensitive LNCaP prostate cancer cells; this triggers a DNA damage response...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Reddy, Vidyavathi, Iskander, Asm, Hwang, Clara, Divine, George, Menon, Mani, Barrack, Evelyn R., Reddy, G. Prem-Veer, Kim, Sahn-Ho
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6513077/
https://ncbi.nlm.nih.gov/pubmed/31083651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0211090
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