6,7-Dihydroxy-2-(4′-hydroxyphenyl)naphthalene induces HCT116 cell apoptosis through activation of endoplasmic reticulum stress and the extrinsic apoptotic pathway

BACKGROUND: Colorectal cancer is the third leading cause of cancer-related deaths worldwide, and therefore, the development of novel drugs for its prevention and therapy are urgently required. This study aimed to determine the molecular mechanism of 6,7-dihydroxy-2-(4′-hydroxyphenyl) naphthalene (PN...

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Bibliographic Details
Published in:Drug Des Devel Ther
Main Authors: Chiu, Ching-Feng, Lai, Guan-Ying, Chen, Chung-Hwan, Chiu, Chien-Chao, Hung, Shao-Wen, Chang, Chi-Fen
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2019
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6512798/
https://ncbi.nlm.nih.gov/pubmed/31190740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S193914
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