Spectral Imaging of FRET-Based Sensors Reveals Sustained cAMP Gradients in Three Spatial Dimensions

Cyclic AMP is a ubiquitous second messenger that orchestrates a variety of cellular functions over different timescales. The mechanisms underlying specificity within this signaling pathway are still not well understood. Several lines of evidence suggest the existence of spatial cAMP gradients within...

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Bibliographic Details
Published in:Cytometry A
Main Authors: Annamdevula, Naga S., Sweat, Rachel, Griswold, John R., Trinh, Kenny, Hoffman, Chase, West, Savannah, Deal, Joshua, Britain, Andrea L., Jalink, Kees, Rich, Thomas C., Leavesley, Silas J.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6512796/
https://ncbi.nlm.nih.gov/pubmed/30176184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cyto.a.23572
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