Costunolide Inhibits the Growth of OAW42-A Multidrug-Resistant Human Ovarian Cancer Cells by Activating Apoptotic and Autophagic Pathways, Production of Reactive Oxygen Species (ROS), Cleaved Caspase-3 and Cleaved Caspase-9

BACKGROUND: Worldwide, ovarian cancer has a high mortality rate due to the difficulty in diagnosing early-stage disease and resistance to chemotherapy agents. Costunolide is a plant-derived sesquiterpene lactone with anti-oxidant properties. This study aimed to investigate the effects of costunolide...

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Vydáno v:Med Sci Monit
Hlavní autoři: Fang, Yichen, Li, Jie, Wu, Yinan, Gui, Jing, Shen, Yang
Médium: Artigo
Jazyk:Inglês
Vydáno: International Scientific Literature, Inc. 2019
Témata:
Lab/In Vitro Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6512352/
https://ncbi.nlm.nih.gov/pubmed/31043579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.914029
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