Loss of Claudin-3 Expression Induces IL6/gp130/Stat3 Signaling to Promote Colon Cancer Malignancy by Hyperactivating Wnt/β-Catenin signaling

The Hyperactivated Wnt/β-catenin signaling acts as a switch to induce EMT and promote colorectal cancer. However, due to its essential role in gut homeostasis, therapeutic targeting of this pathway has proven challenging. Additionally, IL-6/Stat-3 signaling, activated by microbial translocation thro...

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Pubblicato in:Oncogene
Autori principali: Ahmad, Rizwan, Kumar, Balawant, Chen, Zhimin, chen, Xi, Müller, Dominik, Lele, Subodh M., Washington, Mary Kay, Batra, Surinder K., Dhawan, Punita, Singh, Amar B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6512312/
https://ncbi.nlm.nih.gov/pubmed/28783170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.259
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