Esc2 promotes telomere stability in response to DNA replication stress

Telomeric regions of the genome are inherently difficult-to-replicate due to their propensity to generate DNA secondary structures and form nucleoprotein complexes that can impede DNA replication fork progression. Precisely how cells respond to DNA replication stalling within a telomere remains poor...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Jørgensen, Signe W, Liberti, Sascha E, Larsen, Nicolai B, Lisby, Michael, Mankouri, Hocine W, Hickson, Ian D
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Genome Integrity, Repair and Replication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6511870/
https://ncbi.nlm.nih.gov/pubmed/30838410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz158
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