Metformin mitigates autoimmune insulitis by inhibiting Th1 and Th17 responses while promoting Treg production

Type 1 diabetes mellitus (T1DM) is still one of the major threats on global public health. This autoimmune condition is mainly caused by the imbalance of auto-reactive inflammatory effector T cells (Teffs) and protective regulatory T cells (Tregs). Therefore, inhibiting the development of Teffs and/...

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Pubblicato in:Am J Transl Res
Autori principali: Duan, Wu, Ding, Yunchuan, Yu, Xuefeng, Ma, Dongxia, Yang, Bo, Li, Yi, Huang, Li, Chen, Zhonghua, Zheng, Junmeng, Yang, Chao
Natura: Artigo
Lingua:Inglês
Pubblicazione: e-Century Publishing Corporation 2019
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6511786/
https://ncbi.nlm.nih.gov/pubmed/31105845
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