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The structure of Trametes versicolor glutathione transferase Omega 3S bound to its conjugation product glutathionyl‐phenethylthiocarbamate reveals plasticity of its active site

Trametes versicolor glutathione transferase Omega 3S (TvGSTO3S) catalyzes the conjugation of isothiocyanates (ITC) with glutathione (GSH). Previously, this isoform was investigated in depth both biochemically and structurally. Structural analysis of complexes revealed the presence of a GSH binding s...

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Détails bibliographiques
Publié dans:Protein Sci
Auteurs principaux: Schwartz, Mathieu, Perrot, Thomas, Morel‐Rouhier, Mélanie, Mulliert, Guillermo, Gelhaye, Eric, Didierjean, Claude, Favier, Frédérique
Format: Artigo
Langue:Inglês
Publié: John Wiley & Sons, Inc. 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6511745/
https://ncbi.nlm.nih.gov/pubmed/30972861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3620
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