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Side chain electrostatic interactions and pH‐dependent expansion of the intrinsically disordered, highly acidic carboxyl‐terminus of γ‐tubulin

Intramolecular electrostatic attraction and repulsion strongly influence the conformational sampling of intrinsically disordered proteins and domains (IDPs). In order to better understand this complex relationship, we have used nuclear magnetic resonance to measure side chain pK(a) values and pH‐dep...

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Detalhes bibliográficos
Publicado no:Protein Sci
Main Authors: Payliss, Brandon J., Vogel, Jackie, Mittermaier, Anthony K.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6511730/
https://ncbi.nlm.nih.gov/pubmed/30968464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3618
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