Muscle and not neuronal biomarkers correlate with severity in spinal and bulbar muscular atrophy

OBJECTIVE: To determine whether blood biomarkers of neuronal damage (neurofilament light chain [NfL]), muscle damage (creatine kinase [CK]), and muscle mass (creatinine) are altered in spinal and bulbar muscular atrophy (SBMA) and can be used as biomarkers for disease severity. METHODS: In this mult...

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Detalhes bibliográficos
Publicado no:Neurology
Main Authors: Lombardi, Vittoria, Querin, Giorgia, Ziff, Oliver J., Zampedri, Luca, Martinelli, Ilaria, Heller, Carolin, Foiani, Martha, Bertolin, Cinzia, Lu, Ching-Hua, Malik, Bilal, Allen, Kezia, Rinaldi, Carlo, Zetterberg, Henrik, Heslegrave, Amanda, Greensmith, Linda, Hanna, Michael, Soraru, Gianni, Malaspina, Andrea, Fratta, Pietro
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6511101/
https://ncbi.nlm.nih.gov/pubmed/30787165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000007097
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